Imidazole → HCID 66975068, compound

Participants

Reaction Steps

To a solution of (1RS,2RS)-2-[(benzylamino)methyl]-1-(3,4-dichlorophenyl)propane-1,3-diol (3.44 g) in DMF (30 ml) were added tert-butylchlorodimethylsilane (1.68 g) and imidazole (1.03 g) under ice-cooling, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with ethyl acetate. The diluted solution was washed with distilled water, saturated aqueous sodium hydrogen carbonate and brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (2.98 g).

Provenance & Evidence