Chloroacetyl chloride → HCID 66975664, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (1RS,2RS)-3-(benzylamino)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1-(3,4-dichlorophenyl)propan-1-ol (2.98 g) and triethylamine (1.10 mL) in THF (30 mL) was added chloroacetyl chloride (0.526 mL) under ice-cooling, and the mixture was stirred at 0° C. for 4 hr. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with ethyl acetate. The diluted solution was washed with distilled water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (2.95 g).

Provenance & Evidence