Sodium t-butoxide → HCID 66974911, compound

Participants

Reaction Steps

To a solution of N-benzyl-N-[(2RS,3RS)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(3,4-dichlorophenyl)-3-hydroxypropyl]-2-chloroacetamide (2.72 g) in THF (100 ml) was added sodium tert-butoxide (621 mg) under ice-cooling, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with ethyl acetate. The diluted solution was washed with distilled water and brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound (2.51 g).

Provenance & Evidence