Sodium Hydroxide → HCID 66975115, compound

Participants

Reaction Steps

To a solution of lithium aluminum hydride (347 mg) in diethyl ether (30 mL) was added, under a nitrogen stream, aluminum(III) chloride (406 mg) at room temperature, and the mixture was stirred at room temperature for 30 min. The reaction mixture was cooled to −78° C., a solution of (6RS,7RS)-4-benzyl-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-3-one (2.51 g) in THF (20 mL) was added dropwise, and the mixture was stirred at 0° C. for 3 hr. To the reaction mixture was added 1 N aqueous sodium hydroxide solution (5 mL) at −78° C., and the mixture was stirred at room temperature for 2 hr, and filtered through celite. The filtrate was concentrated under reduced pressure to give the title compound (2.42 g).

Provenance & Evidence