Methyl iodide → HCID 66975157, compound

Participants

Reaction Steps

To a solution of sodium hydride (10.5 mg) in THF (1 mL) was added a solution of tert-butyl (6RS,7RS)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate (65.7 mg) in THF (1 ml), and the mixture was stirred at room temperature for 30 min. To the reaction mixture was added methyl iodide (49.7 mg), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with ethyl acetate. The diluted solution was washed with distilled water and brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (58.4 mg).

Provenance & Evidence