Sodium Azide → HCID 86663848, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (6RS,7RS)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate (830 mg) in DMF (10 mL) was added sodium azide (178 mg), and the mixture was stirred at 70° C. for 18 hr. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with ethyl acetate. The diluted solution was washed with distilled water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (723 mg).

Provenance & Evidence