Ethanol hydrochloride → HCID 77244075, compound

HRID 1022546Notes

Reaction equation

HRID 1022546 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH:10]2[CH2:23][OH:24])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.C(O)C>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:15][CH2:14][CH2:13][NH:12][CH2:11][CH:10]2[CH2:23][OH:24])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 66975761HCID 66975761, compound

Product 1

HCID 77244075HCID 77244075, compoundYield 138.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl (6RS,7SR)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate (150 mg) in ethanol (2 mL) was added 2 N hydrogen chloride-ethanol solution (3.0 mL), and the mixture was stirred at room temperature for 14 hr. The oil obtained by concentration under reduced pressure was crystallized from ethyl acetate-ethanol, and the crystals were recrystallized from ethyl acetate-ethanol to give the title compound (86.5 mg).

Workup

  1. customThe oil obtained by concentration under reduced pressure
  2. customwas crystallized from ethyl acetate-ethanol
  3. customthe crystals were recrystallized from ethyl acetate-ethanol

Sources & evidence

ORD record
ord-2026eac6ae6c4edab823db71c9500390
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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