Triethylamine → HCID 66975214, compound

Participants

Reaction Steps

To a solution of (1RS,2SR)-2-[(benzylamino)methyl]-1-(4-chloro-3-fluorophenyl)propane-1,3-diol (44.5 g) and triethylamine (21.1 ml) in THF (416 mL) was added a solution of tert-butylchlorodimethylsilane (22.8 g) in THF (42 mL) under ice-cooling, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with ethyl acetate. The diluted solution was washed with distilled water and brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (NH, hexane/ethyl acetate) to give the title compound (29.3 g).

Provenance & Evidence