Sodium Hydroxide → HCID 66975364, compound

Participants

Reaction Steps

To a solution of N-benzyl-N-[(2RS,3SR)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(4-chloro-3-fluorophenyl)-3-hydroxypropyl]-2-chloroacetamide (34.5 g) in THF (1340 mL) was added 1 N aqueous sodium hydroxide solution (80.0 mL) under ice-cooling, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with ethyl acetate. The diluted solution was washed with distilled water and brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound (31.5 g).

Provenance & Evidence