Sodium potassium tartrate tetrahydrate → HCID 66975631, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of aluminum(III) chloride (5.28 g) in THF (396 mL) was added, under a nitrogen stream, lithium aluminum hydride (4.51 g) under ice-cooling, and the mixture was stirred at 0° C. for 1 hr. To the reaction mixture was added dropwise a solution of (6RS,7SR)-4-benzyl-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-3-one (31.5 g) in THF (264 ml), and the mixture was stirred at 0° C. for 2 hr. To the reaction mixture was added aqueous potassium sodium (+)-tartrate tetrahydrate (93.0 g) solution at 0° C., and the mixture was stirred at room temperature overnight, and filtered through celite. The obtained oil was diluted with ethyl acetate, and the mixture was washed with distilled water and brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound (26.4 g).

Provenance & Evidence