HCID 66976330, compound → HCID 66975233, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (2RS)-2-(3,4-dichlorophenyl)-2-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate (3.18 g) in acetonitrile (80 ml) and water (20 mL) was added ceric ammonium nitrate (10.8 g) at 0° C., and the mixture was stirred at 0° C. for 1 hr. The reaction mixture was diluted with water, and the mixture was extracted with ethyl acetate. The obtained extract was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (1.9 g).

Provenance & Evidence