Water → HCID 66975148, compound

Participants

Reaction Steps

A solution of [(6RS,7SR)-4-benzyl-6-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methanol (1.63 g), triethylamine (0.741 mL), tert-butyldimethylsilyl chloride (738 mg) and 4-dimethylaminopyridine (catalytic amount) in DMF (10 ml) was stirred at room temperature for 2 hr. The reaction mixture was added to water, and the mixture was extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.93 g).

Provenance & Evidence