Ethanol hydrochloride → HCID 66975073, compound

HRID 1022611Notes

Reaction equation

HRID 1022611 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][C@H:10]2[CH2:23][NH:24][C:25](=[O:29])[CH2:26][O:27][CH3:28])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.C(O)C>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[O:15][CH2:14][CH2:13][NH:12][CH2:11][C@H:10]2[CH2:23][NH:24][C:25](=[O:29])[CH2:26][O:27][CH3:28])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 66975617HCID 66975617, compound

Product 1

HCID 66975073HCID 66975073, compoundYield 181%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(methoxyacetyl)amino]methyl}-1,4-oxazepane-4-carboxylate (161 mg) in ethanol (1 ml) was added 14.0 M hydrogen chloride-ethanol solution (2 mL), and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure. The obtained crystals were recrystallized from ethanol to give the title compound (125 mg) as colorless crystals.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe obtained crystals were recrystallized from ethanol

Sources & evidence

ORD record
ord-7bf6a6a87c764d8fbe8691280a4c39c9
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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