Hydrogen chloride-ethyl acetate → HCID 66975583, compound

HRID 1022613Notes

Reaction equation

HRID 1022613 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][C@H:10]2[CH2:23][NH:24][S:25]([CH3:28])(=[O:27])=[O:26])[CH:5]=[CH:6][C:7]=1[Cl:8].C(OCC)(=O)C.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[O:15][CH2:14][CH2:13][NH:12][CH2:11][C@H:10]2[CH2:23][NH:24][S:25]([CH3:28])(=[O:26])=[O:27])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66975685HCID 66975685, compound

Product 1

HCID 66975583HCID 66975583, compoundYield 156.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)amino]methyl}-1,4-oxazepane-4-carboxylate (162 mg) in ethanol (0.5 mL) was added 4.0 M hydrogen chloride-ethyl acetate solution (3 mL), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure. The obtained crystals were recrystallized from ethanol-water to give the title compound (109 mg) as colorless crystals.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe obtained crystals were recrystallized from ethanol-water

Sources & evidence

ORD record
ord-3c1171a7d9654b6ea89a89a92cc4b996
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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