Hydrogen chloride-ethyl acetate → N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]sulfamide monohydrochloride

Participants

Reaction Steps

To tert-butyl (6R,7S)-6-{[(tert-butoxycarbonyl)sulfamoyl]amino}-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (200 mg) was added 4.0 M hydrogen chloride-ethyl acetate solution (4 mL), and the mixture was stirred at room temperature for 2 hr. The residue obtained by concentration under reduced pressure was washed with ethyl acetate-hexane to give the title compound (105 mg).

Provenance & Evidence