Hydrogen chloride-ethyl acetate → N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-(1-methylethoxy)acetamide monohydrochloride

Participants

Reaction Steps

To tert-butyl (6R,7R)-7-(4-chloro-3-fluorophenyl)-6-({[(1-methylethoxy)acetyl]amino}methyl)-1,4-oxazepane-4-carboxylate (384 mg) was added 4.0 M hydrogen chloride-ethyl acetate solution (6.28 ml), and the mixture was stirred at room temperature for 1 hr. The residue obtained by concentration under reduced pressure was crystallized from ethanol-hexane solvent to give the title compound (153.4 mg).

Provenance & Evidence