反应详情

14 N Hydrogen chloride-ethanol solution (1 mL, 14.00 mmol) was added to a solution (3 mL) of tert-butyl (6R,7R)-7-(4-chloro-3-fluorophenyl)-6-[(2-oxopyridin-1(2H)-yl)methyl]-1,4-oxazepane-4-carboxylate (267 mg, 0.61 mmol) in ethanol, and the mixture was stirred at room temperature for 3 hr. The residue was concentrated, diethyl ether was added, and the mixture was stirred for a while. The insoluble material was collected by filtration to give the title compound (227 mg, 0.608 mmol, 100%).

1. concentrationThe residue was concentrated
2. additiondiethyl ether was added
3. stirringthe mixture was stirred for a while
4. filtrationThe insoluble material was collected by filtration