HCID 66975468, compound → HCID 66975729, compound

Participants

Reaction Steps

To a solution of (2RS)-(3,4-dichlorophenyl)[(4RS)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanenitrile (10.0 g) in toluene (100 ml) was added dropwise 1.5 M diisobutylaluminum hydride/toluene solution (51.3 under nitrogen purging at −78° C., and the mixture was stirred for 3 hr. The reaction was quenched with water at −78° C., aqueous potassium carbonate solution was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated to give the title compound (10.2 g) as a colorless oil. This was used for the next step without purification.

Provenance & Evidence