Hydrochloric Acid → HCID 66975619, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2RS)—N-benzyl-2-(3,4-dichlorophenyl)-2-[(4RS)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanamine (7.95 g) in THF (32 mL) was added 1.0 N hydrochloric acid (31.4 ml) at room temperature, and the mixture was stirred under nitrogen purging at 50° C. for 3 hr. Saturated aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated to give the title compound (7.50 g) as a pale-brown oil. This was used without purification for the next step.

Provenance & Evidence