Ethanol hydrochloride → HCID 66975266, compound

HRID 1022651Notes

Reaction equation

HRID 1022651 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:15]([C@H:16]([OH:19])[CH2:17][OH:18])[O:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.C(O)C>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:15]([C@H:16]([OH:19])[CH2:17][OH:18])[O:14][CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 66975127HCID 66975127, compound

Product 1

HCID 66975266HCID 66975266, compoundYield 160.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl (6R,7R)-6-(3,4-dichlorophenyl)-7-[(1R)-1,2-dihydroxyethyl]-1,4-oxazepane-4-carboxylate (170 mg) obtained in Example 45, step M) in ethanol (5 ml) was added 12 mol/kg hydrogen chloride-ethanol solution (5 mL), and the mixture was stirred at room temperature for 15 min. The solvent was evaporated under reduced pressure, and the residue was crystallized from water-ethanol-diethyl ether to give the title compound (115 mg) as colorless crystals.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was crystallized from water-ethanol-diethyl ether

Sources & evidence

ORD record
ord-aa87901e26ad408c83da1779eabbdd4d
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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