Hydrogen chloride-ethyl acetate → HCID 86663859, compound

HRID 1022656Notes

Reaction equation

HRID 1022656 reaction equation
C(OC([N:8]1[CH2:14][C@H:13]([CH2:15][O:16][C:17]2[CH:25]=[CH:24][CH:23]=[CH:22][C:18]=2[C:19]([OH:21])=[O:20])[C@H:12]([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=2)[O:11][CH2:10][CH2:9]1)=O)(C)(C)C.C(OCC)(=O)C.Cl>>[ClH:32].[Cl:33][C:28]1[CH:27]=[C:26]([C@@H:12]2[O:11][CH2:10][CH2:9][NH:8][CH2:14][C@@H:13]2[CH2:15][O:16][C:17]2[CH:25]=[CH:24][CH:23]=[CH:22][C:18]=2[C:19]([OH:21])=[O:20])[CH:31]=[CH:30][C:29]=1[Cl:32]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68278269HCID 68278269, compound

Product 1

HCID 86663859HCID 86663859, compoundYield 91.8%

Procedure

To 2-{[(6R*,7R*)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methoxy}benzoic acid (50 mg) was added 4.0 M hydrogen chloride-ethyl acetate solution (4 mL), and the mixture was stirred at room temperature for 1 hr. The residue obtained by concentration under reduced pressure was washed with ethyl acetate-hexane to give the title compound (20 mg).

Workup

  1. customThe residue obtained by concentration under reduced pressure
  2. washwas washed with ethyl acetate-hexane

Sources & evidence

ORD record
ord-365e2d44ae274c39ade4d4a27b6201e4
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

Loading…