Imidazole → HCID 66975401, compound

Participants

Reaction Steps

To a solution of (6RS,7SR)-4-benzyl-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-ol (27.7 g) in DMF (154 mL) were added tert-butylchlorodimethylsilane (17.8 g) and imidazole (10.7 g), and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with water-ethyl acetate for partitioning, and the organic layer was washed with distilled water and brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (37.0 g).

Provenance & Evidence