tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]-1,4-oxazepane-4-carboxylate → tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(3-ethoxy-3-oxopropyl)-1,4-oxazepane-4-carboxylate

Participants

Reaction Steps

To a solution (1.1 mL) of tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]-1,4-oxazepane-4-carboxylate (100 mg) in methanol was added, under a nitrogen atmosphere, 3% platinum/activated carbon (23 mg), and the mixture was stirred under a hydrogen atmosphere for 1 hr. The reaction mixture was filtered through celite, and concentrated under reduced pressure to give the title compound (113 mg).

Provenance & Evidence