Sodium Bicarbonate → HCID 66975307, compound

Participants

Reaction Steps

To a solution of tert-butyl (6RS,7RS)-6-(2-amino-2-oxoethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (100 mg) in ethyl acetate (0.5 ml) was added 2 N hydrogen chloride-ethanol solution (1 mL), and the mixture was stirred at room temperature for 3 hr. To the reaction mixture was added saturated aqueous sodium hydrogen carbonate, and the mixture was extracted twice with ethyl acetate. The combined organic layers were washed with brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. To the residue was added 1 N hydrochloric acid. The solvent was evaporated under reduced pressure to give the title compound (14 mg).

Provenance & Evidence