1-Tetrazolylacetic acid → HCID 66976208, compound

HRID 1022691Notes

Reaction equation

HRID 1022691 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[N:25]1([CH2:30][C:31](O)=[O:32])[CH:29]=[N:28][N:27]=[N:26]1>>[ClH:16].[Cl:17][C:12]1[CH:11]=[C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:31](=[O:32])[CH2:30][N:25]2[CH:29]=[N:28][N:27]=[N:26]2)[CH:15]=[CH:14][C:13]=1[Cl:16]

Participants

3

Reactant 2

HCID 5432071-Tetrazolylacetic acidHCID 66975351HCID 66975351, compound

Product 1

HCID 66976208HCID 66976208, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate and 2-(1H-tetrazol-1-yl)acetic acid, and by a method similar to that in Example 39, steps A and B, the title compound was obtained.

Sources & evidence

ORD record
ord-36de037bb4f647b6b4364dd8a01cd2e7
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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