2-(2-Oxopyrrolidin-1-yl)acetic acid → HCID 66975509, compound

HRID 1022693Notes

Reaction equation

HRID 1022693 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[O:25]=[C:26]1[CH2:30][CH2:29][CH2:28][N:27]1[CH2:31][C:32](O)=[O:33]>>[ClH:16].[Cl:17][C:12]1[CH:11]=[C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:32](=[O:33])[CH2:31][N:27]2[CH2:28][CH2:29][CH2:30][C:26]2=[O:25])[CH:15]=[CH:14][C:13]=1[Cl:16]

Participants

3

Reactant 2

HCID 31466872-(2-Oxopyrrolidin-1-yl)acetic acidHCID 66975351HCID 66975351, compound

Product 1

HCID 66975509HCID 66975509, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate and (2-oxopyrrolidin-1-yl)acetic acid, and by a method similar to that in Example 39, the title compound was obtained.

Sources & evidence

ORD record
ord-d184ac8c7ccc42e3afef2673cc03687e
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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