Hydrogen chloride-ethyl acetate → HCID 66976165, compound

Participants

Reaction Steps

To 2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid (102 mg) was added 4.0 M hydrogen chloride-ethyl acetate solution (4 mL), and the mixture was stirred at room temperature for 1 hr. The residue obtained by concentration under reduced pressure was separated by HPLC (C18, mobile phase: water/acetonitrile (containing 5 mM AcONH4)), and the obtained fraction was concentrated under reduced pressure to give the title compound (17 mg).

Provenance & Evidence