Ammonium Chloride → HCID 178452469, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (6R,7R)-6-({[(3-cyanophenyl)carbonyl]amino}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (100 mg) in DMF (4 mL) were added sodium azide (38.7 mg) and ammonium chloride (37.1 mg) at room temperature, and the mixture was stirred at 100° C. overnight. The reaction mixture was diluted with ethyl acetate. The diluted solution was washed with distilled water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (32 mg).

Provenance & Evidence