Morpholine → HCID 66975402, compound

HRID 1022699Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][C@H:10]2[CH2:23][NH:24][C:25]([O:27]C2C=CC([N+]([O-])=O)=CC=2)=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[NH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[O:15][CH2:14][CH2:13][NH:12][CH2:11][C@H:10]2[CH2:23][NH:24][C:25]([N:37]2[CH2:42][CH2:41][O:40][CH2:39][CH2:38]2)=[O:27])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

Reactant 2

HCID 8083Morpholine

HCID 66976231HCID 66976231, compound

Product 1

HCID 66975402HCID 66975402, compound

Procedure

Using tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(4-nitrophenoxy)carbonylamino]methyl}-1,4-oxazepane-4-carboxylate and morpholine, and by a method similar to that in Example 158, steps B and C, the title compound was obtained.

Sources & evidence

ORD record: ord-34211e5b940d4920ac697c651c69592c
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722662B2

Reaction notes

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