HCID 66975176, compound → HCID 66975848, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (7.8 mL) of tert-butyl (6R,7R)-6-{[(2-bromophenyl)sulfanyl]methyl}-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (424 mg) in DMF was added copper cyanide (139 mg), and the mixture was stirred under an argon atmosphere at 150° C. overnight. The reaction mixture was filtered through celite, distilled water was added, and the mixture was extracted with ethyl acetate. The extract was washed with distilled water and brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (146 mg).

Provenance & Evidence