Hydrogen Peroxide → HCID 66975405, compound

Participants

Reaction Steps

33% Aqueous hydrogen peroxide (1 mL) was added to a solution of tert-butyl (6RS,7SR)-6-[(3-cyanopyridin-2-yl)oxy]-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (100 mg) and potassium carbonate (45 mg) in DMSO (3 mL), and the mixture was stirred at room temperature for 2 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography and HPLC to give the title compound (57 mg).

Provenance & Evidence