8-Oxa-3-aza-bicyclo(3.2.1)octane hydrochloride → HCID 66976109, compound

HRID 1022736Notes

Reaction equation

HRID 1022736 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C@H:7]1[C@H:13]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([F:21])[CH:15]=2)[O:12][CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]1)=[O:4].[ClH:29].[CH:30]12[O:37][CH:34]([CH2:35][CH2:36]1)[CH2:33][NH:32][CH2:31]2>>[ClH:1].[ClH:29].[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C@@H:13]2[O:12][CH2:11][CH2:10][NH:9][CH2:8][C@H:7]2[CH2:6][NH:5][C:3](=[O:4])[CH2:2][N:32]2[CH2:31][CH:30]3[O:37][CH:34]([CH2:35][CH2:36]3)[CH2:33]2)=[CH:15][C:16]=1[F:21]

Participants

3

Reactant 2

HCID 219835368-Oxa-3-aza-bicyclo(3.2.1)octane hydrochlorideHCID 66975195HCID 66975195, compound

Product 1

HCID 66976109HCID 66976109, compound

Procedure

Using tert-butyl (6R,7R)-6-{[(chloroacetyl)amino]methyl}-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 8-oxa-3-azabicyclo[3.2.1]octane monohydrochloride, and in the same manner as in Example 336, steps B and C, the title compound was obtained.

Sources & evidence

ORD record
ord-50c3f7809de04b0986983b02d8069186
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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