2-((Pyridin-2-yl)formamido)acetic acid → N-[2-({[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}amino)-2-oxoethyl]pyridine-2-carboxamide monohydrochloride

Participants

Role	Name	HCID	Charge
Reactant	2-((Pyridin-2-yl)formamido)acetic acid	HCID 11788622	—
Reactant	tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate	HCID 66975002	—
Product	N-[2-({[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}amino)-2-oxoethyl]pyridine-2-carboxamide monohydrochloride	HCID 66976410	—

Reaction Steps

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and N-(pyridin-2-ylcarbonyl)glycine, and by a method similar to that of Example 39, the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08722662B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-69bcf54c1e344bfba0235ce7c5fede1c
Source note	uspto-grants-2014_05