56546-36-2 → HCID 66975858, compound

HRID 1022743Notes

Reaction equation

HRID 1022743 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[O:25]=[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][N:27]1[CH2:32][C:33](O)=[O:34]>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:33](=[O:34])[CH2:32][N:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]2=[O:25])=[CH:11][C:12]=1[F:17]

Participants

3

Reactant 2

HCID 56531656546-36-2HCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

Product 1

HCID 66975858HCID 66975858, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and (2-oxopyridin-1(2H)-yl)acetic acid, and by a method similar to that of Example 39, the title compound was obtained.

Sources & evidence

ORD record
ord-e7a760b2a74b41afb4d57940cd167e5e
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

Loading…