tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate → HCID 66975140, compound

HRID 1022744Notes

Reaction equation

HRID 1022744 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[F:25][C:26]1[C:27]([O:32][CH2:33][C:34](O)=[O:35])=[N:28][CH:29]=[CH:30][CH:31]=1>>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:34](=[O:35])[CH2:33][O:32][C:27]2[C:26]([F:25])=[CH:31][CH:30]=[CH:29][N:28]=2)=[CH:11][C:12]=1[F:17]

Participants

3

Reactant 2

HCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylateHCID 66975791HCID 66975791, compound

Product 1

HCID 66975140HCID 66975140, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and [(3-fluoropyridin-2-yl)oxy]acetic acid, and by a method similar to that of Example 39, followed by neutralization, the title compound was obtained.

Sources & evidence

ORD record
ord-576ed2a18ebe44f3a6606fcaaa2d19cb
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

Loading…