tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate → HCID 66975674, compound

HRID 1022745Notes

Reaction equation

HRID 1022745 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[CH3:25][C:26]1[O:30][N:29]=[C:28]([C:31]2[CH:39]=[CH:38][CH:37]=[CH:36][C:32]=2[C:33](O)=[O:34])[N:27]=1>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:33](=[O:34])[C:32]2[CH:36]=[CH:37][CH:38]=[CH:39][C:31]=2[C:28]2[N:27]=[C:26]([CH3:25])[O:30][N:29]=2)=[CH:11][C:12]=1[F:17]

Participants

3

Reactant 2

HCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylateHCID 66976761HCID 66976761, compound

Product 1

HCID 66975674HCID 66975674, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 2-(5-methyl-1,2,4-oxadiazol-3-yl)benzoic acid, and by a method similar to that of Example 39, the title compound was obtained.

Sources & evidence

ORD record
ord-2b24acaf8a9f4eee84eca13c0ee54cdc
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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