Nicotinic Acid → HCID 66976176, compound

HRID 1022753Notes

Reaction equation

HRID 1022753 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[N:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31](O)=[O:32])[CH:26]=1>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:31]([C:27]2[CH:26]=[N:25][CH:30]=[CH:29][CH:28]=2)=[O:32])=[CH:11][C:12]=1[F:17]

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

Product 1

HCID 66976176HCID 66976176, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and pyridine-3-carboxylic acid, and by a method similar to that of Example 39, the title compound was obtained.

Sources & evidence

ORD record
ord-fb0ec1b6e09b4f20bbcf06924f7e23ad
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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