2-Methoxynicotinic acid → HCID 66975457, compound

HRID 1022754Notes

Reaction equation

HRID 1022754 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.C[O:26][C:27]1[C:32]([C:33](O)=[O:34])=[CH:31][CH:30]=[CH:29][N:28]=1>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:33]([C:32]2[C:27](=[O:26])[NH:28][CH:29]=[CH:30][CH:31]=2)=[O:34])=[CH:11][C:12]=1[F:17]

Participants

3

Reactant 2

HCID 7080932-Methoxynicotinic acidHCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

Product 1

HCID 66975457HCID 66975457, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 2-methoxypyridine-3-carboxylic acid, and by a method similar to that of Example 39, the title compound was obtained.

Sources & evidence

ORD record
ord-e665ea34cd334fee86b57c10d2da9f9e
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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