3-Aminopicolinic acid → HCID 66976757, compound

HRID 1022755Notes

Reaction equation

HRID 1022755 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:4]1.[NH2:25][C:26]1[C:27]([C:32](O)=[O:33])=[N:28][CH:29]=[CH:30][CH:31]=1>>[NH2:25][C:26]1[C:27]([C:32]([NH:1][CH2:2][C@H:3]2[C@H:9]([C:10]3[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=3)[O:8][CH2:7][CH2:6][N:5]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:4]2)=[O:33])=[N:28][CH:29]=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 738363-Aminopicolinic acidHCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

Product 1

HCID 66976757HCID 66976757, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 3-aminopyridine-2-carboxylic acid, and by a method similar to that of Example 39, step A, the title compound was obtained.

Sources & evidence

ORD record
ord-3e154fc138694398b24dafad103f4cb4
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

Loading…