Potassium Iodide → HCID 66975885, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (6R,7R)-6-({[bromo(difluoro)acetyl]amino}methyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate (176 mg), pyrrolidine (0.085 mL) and potassium iodide (11.3 mg) in THF (3.4 ml) was added potassium carbonate (282 mg), and the mixture was stirred at 60° C. overnight. To the reaction mixture was added distilled water, and the mixture was extracted with ethyl acetate. The extract was washed with distilled water and brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate). The obtained residue was subjected to an operation similar to that of Example 38, step E to give the title compound (11.7 mg).

Provenance & Evidence