Sodium hydride → HCID 66975082, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (6R,7R)-7-(4-chloro-3-fluorophenyl)-6-({[(3-chloropropyl)carbamoyl]amino}methyl)-1,4-oxazepane-4-carboxylate (531 mg) in DMF (22 mL) was added sodium hydride (48.8 mg, 60% in oil) under ice-cooling, and the mixture was stirred at 0° C. for 2 hr. To the reaction mixture was added distilled water, and the mixture was extracted with ethyl acetate. The extract was washed with distilled water and brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (563 mg).

Provenance & Evidence