HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl carbazate → 1-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2(1H)-one monohydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl carbazate | HCID 80519 | — |
| Reactant | tert-butyl (6R,7R)-6-[(3-carbamothioyl-2-oxopyridin-1(2H)-yl)methyl]-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate | HCID 86663873 | — |
| Product | 1-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2(1H)-one monohydrochloride | HCID 136340702 | — |
Reaction Steps
Using tert-butyl (6R,7R)-6-[(3-carbamothioyl-2-oxopyridin-1(2H)-yl)methyl]-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and methyl carbazate, and in the same manner as in Example 200, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722662B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-bc0e855987cb4b478b4068a25e0970c9 |
| Source note | uspto-grants-2014_05 |