Sodium Bicarbonate → HCID 66976184, compound

Participants

Reaction Steps

A solution of tert-butyl (6R,7R)-6-{2-[(2-aminophenyl)amino]-2-oxoethyl}-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate (155 mg) in acetic acid (1.1 mL) was stirred at 100° C. for 2 hr. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed with distilled water and brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (128 mg).

Provenance & Evidence