tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate → tert-butyl (6R,7R)-7-(4-chloro-3-fluorophenyl)-6-{[(4-cyano-1,3-benzoxazol-2-yl)amino]methyl}-1,4-oxazepane-4-carboxylate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate	HCID 66975002	—
Edukt	2-Chlorobenzo[d]oxazole-4-carbonitrile	HCID 66975370	—
Produkt	tert-butyl (6R,7R)-7-(4-chloro-3-fluorophenyl)-6-{[(4-cyano-1,3-benzoxazol-2-yl)amino]methyl}-1,4-oxazepane-4-carboxylate	HCID 66975355	—

Reaktionsschritte

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 2-chloro-1,3-benzoxazole-4-carbonitrile, and in the same manner as in Example 391, step A, the title compound was obtained.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08722662B2
Quelldatensatz	uspto-grants-2014_05
ORD ID	ord-7e0baa1dec054773a064af61f00cda2a
Quellennotiz	uspto-grants-2014_05