(2-Bromoethoxy)-tert-butyldimethylsilane → HCID 66976622, compound

HRID 1022774Notes

Reaction equation

HRID 1022774 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@@:9]2([CH2:23][OH:24])[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Br[CH2:26][CH2:27][O:28][Si](C(C)(C)C)(C)C>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@@:9]2([CH2:23][O:24][CH2:26][CH2:27][OH:28])[O:15][CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 3608067(2-Bromoethoxy)-tert-butyldimethylsilaneHCID 66974988HCID 66974988, compound

Product 1

HCID 66976622HCID 66976622, compound

Procedure

Using tert-butyl (7S)-7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate and (2-bromoethoxy)(tert-butyl)dimethylsilane, and by a method similar to that of Example 363, step B and Example 39, step B, the title compound was obtained.

Sources & evidence

ORD record
ord-77bcbdd65af34df6a845420488019b96
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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