2-Bromoacetamide → HCID 66976022, compound

HRID 1022776Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]2([CH2:23][OH:24])[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Br[CH2:26][C:27]([NH2:29])=[O:28]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]2([CH2:23][O:24][CH2:26][C:27]([NH2:29])=[O:28])[O:15][CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

Reactant 2

HCID 696322-Bromoacetamide

HCID 66975862HCID 66975862, compound

Product 1

HCID 66976022HCID 66976022, compound

Procedure

Using tert-butyl (7R)-7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate and 2-bromoacetamide, and by a method similar to that of Example 363, step B and Example 39, step B, the title compound was obtained.

Sources & evidence

ORD record: ord-eb6ceab019964d18be320c7c419d2cfc
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722662B2

Reaction notes

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