Ethanol hydrochloride → HCID 66976520, compound

HRID 1022778Notes

Reaction equation

HRID 1022778 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH:15]([CH2:16][O:17][CH3:18])[O:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.C(O)C>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH:15]([CH2:16][O:17][CH3:18])[O:14][CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 66976182HCID 66976182, compound

Product 1

HCID 66976520HCID 66976520, compoundYield 191.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl (6RS,7SR)-6-(3,4-dichlorophenyl)-7-(methoxymethyl)-1,4-oxazepane-4-carboxylate (147 mg) in ethanol (1.5 ml) was added 14.0 N hydrogen chloride-ethanol solution (1.2 ml), and the mixture was stirred at room temperature for 1 hr. The residue obtained by concentration under reduced pressure was crystallized from ethanol-diisopropyl ether to give the title compound (118 mg).

Workup

  1. customThe residue obtained by concentration under reduced pressure
  2. customwas crystallized from ethanol-diisopropyl ether

Sources & evidence

ORD record
ord-7cce81924e4b433d866ca28b16e29c2d
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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