Ethyl diazoacetate → HCID 66975633, compound

Participants

Reaction Steps

Under a nitrogen atmosphere at 80° C., to a solution of tert-butyl (6SR,7RS)-6-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate (600 mg) and rhodium acetate dimer (7 mg) in toluene (5 ml) was added dropwise a solution of ethyl diazoacetate (860 mg) in toluene (5 mL) over 10 min. The reaction mixture was stirred at the same temperature for 10 min. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (615 mg).

Provenance & Evidence