Water → HCID 66975642, compound

Participants

Reaction Steps

2 M Aqueous sodium hydroxide solution (0.3 mL) was added dropwise to a solution of tert-butyl (6SR,7RS)-7-({[2-(acetyloxy)-2-methylpropanoyl]amino}methyl)-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (150 mg) in ethanol (5 mL), and the mixture was stirred at room temperature for 1 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (130 mg).

Provenance & Evidence