HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,4-Triazole-1-acetic acid → N-{[(6RS,7SR)-6-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methyl}-2-(1H-1,2,4-triazol-1-yl)acetamide monohydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,4-Triazole-1-acetic acid | HCID 1810180 | — |
| Reactant | tert-butyl (6RS,7SR)-7-(aminomethyl)-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate | HCID 66975190 | — |
| Product | N-{[(6RS,7SR)-6-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methyl}-2-(1H-1,2,4-triazol-1-yl)acetamide monohydrochloride | HCID 66975689 | — |
Reaction Steps
Using tert-butyl (6RS,7SR)-7-(aminomethyl)-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate and 2-(1H-1,2,4-triazol-1-yl)acetic acid, and by a method similar to that of Example 39, step A and Example 449, step B, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722662B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-711878dd5b7e48588d66498cd02cd52b |
| Source note | uspto-grants-2014_05 |